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Inhibiting γ-secretase activity

✍ Scribed by Mullard, Asher

Book ID
109958749
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
80 KB
Volume
8
Category
Article
ISSN
1471-0072

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## Abstract The human amyloid precursor protein (APP) is processed by the nonamyloidogenic and the amyloidogenic catabolic pathways. The sequential cleavage of APP by the β‐ and γ‐secretase activities, known as the amyloidogenic processing of APP, leads to the formation of the amyloid‐β peptide (Aβ