In Search of Immunodominant Minor Histocompatibility Antigens
β Scribed by Perreault, Claude
- Book ID
- 122517557
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 48 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1083-8791
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Minor Histocompatibility (mH) antigens are polymorphic endogenously synthesized products that can be recognized by alloreactive T cells in the context of major histocompatibility complex molecules. In transplant situations where tissue donor and recipient are matched for HLA, mH antigens may trigger
Cytotoxic effector T cells putatively specific for multiple non-H-2 histocompatibility (H) antigens were generated by immunizing and boosting C57BL/6 and B6.C-H-2 d mice with BALB.B and BALB/c stimulator cells, respectively. The generated effectors were tested for cell-mediated lympholysis on a pane