Immunodominance in the immune response to “multiple” histocompatibility antigens

✍ Scribed by Peter J. Wettstein; Donald W. Bailey

• Publisher: Springer-Verlag
• Year: 1982
• Tongue: English
• Weight: 703 KB
• Volume: 16
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00364441

✦ Synopsis

Cytotoxic effector T cells putatively specific for multiple non-H-2 histocompatibility (H) antigens were generated by immunizing and boosting C57BL/6 and B6.C-H-2 d mice with BALB.B and BALB/c stimulator cells, respectively. The generated effectors were tested for cell-mediated lympholysis on a panel of targets whose BALB/c-derived non-H-2 H antigens were donated by CXB recombinant inbred mice. The spectrum of reactivity of cytotoxic effector T cells with CXB targets demonstrated that the effectors did not recognize multiple H antigens but rather preferentially recognized a single immunodominant non-H-2 H antigen. The identity of the immunodominant H antigen was determined by the H-2 genotype of the stimulator cells when (B6 x B6.C-H-2d)F1 cytotoxic effectors were tested. These observations indicate that despite the fact that responders were challenged with more than 40 individual non-H-2 H antigens, they preferentially responded to a single immunodominant antigen.