Improvements in the Formation of Cephalosporins from Penicillin G and Other Penicillins by Bioconversion
✍ Scribed by Adrio, José L.; Demain, Arnold L.
- Book ID
- 126330260
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 69 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1083-6160
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## Abstract Penicillin G acylase (PGA) is an important enzyme for the industrial production of 7‐amino‐3‐deacetoxy cephalosporanic acid (7‐ADCA) from cephalosporin G (Ceph‐G), and 6‐aminopenicillanic acid (6‐APA) from penicillin G (Pen‐G). These products are used for the manufacture of semi‐synthet
A sensitive and convenient method for the simultaneous determination of several of the compounds involved in the biosynthesis of penicillin and cephalosporin is described. The method involves derivatization with a chiral fluorogen (o-phthaldialdehyde with an optically active thiol N-acetyl-L-cystein