Improvement of lipase-catalyzed kinetic resolution by tandem transesterification
β Scribed by A.J.J. Straathof; J.L.L. Rakels; J.B.A. van Tol; J.J. Heijnen
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 532 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0141-0229
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The lipase catalyzed enantiomeric resolution of syn-glycol was carried out to confirm the sector method, which can determine the absolute configuration of anti-and syn-glycol from the 1 H-NMR spectra of bis-2-methoxy-2-trifluoromethyl-2phenylacetic acid (MTPA) esters. The lipase catalyzed transester
The lipase-catalyzed asymmetric transesterification of racemic Β’x-methylene 13-1actones 1 with benzyl alcohol in organic media afforded the optically active I~-lactones and the corresponding 13-hydroxy esters 2 in excellent enantiomeric excess (ee 95-99%).