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Enzymatic preparation of optically active α-methylene β-lactones by lipase-catalyzed kinetic resolution through asymmetric transesterification

✍ Scribed by Waldemar Adam; Peter Groer; Chantu R. Saha-Möller

Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
218 KB
Volume
8
Category
Article
ISSN
0957-4166

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✦ Synopsis

The lipase-catalyzed asymmetric transesterification of racemic ¢x-methylene 13-1actones 1 with benzyl alcohol in organic media afforded the optically active I~-lactones and the corresponding 13-hydroxy esters 2 in excellent enantiomeric excess (ee 95-99%).

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