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Improvement of hepatitis B surface antigen expression by dimethyl sulfoxide in the culture of recombinant Chinese hamster ovary cells

✍ Scribed by Junhui Li; Xiangming Sun; Yuanxing Zhang


Book ID
108252486
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
261 KB
Volume
41
Category
Article
ISSN
1873-3298

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## Abstract The production and specific productivity of hepatitis B surface antigen (HBsAg) in recombinant Chinese hamster ovary (CHO) cells were increased by 81% and threefold, respectively, when supplemented with 1.5% dimethyl sulfoxide (DMSO) in the culture medium. To investigate the mechanism o