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Improved Procedure for Preparation of Covalently Bonded Cellulose Tris-phenylcarbamate Chiral Stationary Phases

✍ Scribed by Qin Feng; Chen Xiao-Ming; Liu Yue-Qi; Zou Han-Fa; Wang Jun-De

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
69 KB
Volume
23
Category
Article
ISSN
0256-7660

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✦ Synopsis

Abstract

The classical method for preparation of covalently boned cellulose derivative chiral stationary phases (CSP) with diisocyanate as spacer was improved. Diisocyanate was firstly allowed to react with 3‐aminopropyltriethoxysilane, and the resulting product was then applied as the spacer reagent to immobilize cellulose derivatives onto silica gel. Influences of the amount and the length of the spacer on the optical resolution ability of the CSP were investigated. Comparing improved procedure to classical diisocyanate method, the cross‐linking between the glucose units of the cellulose derivatives was avoided to the most extent. With the improved procedure, regio‐nonselective ways could be adopted to prepare covalently bonded CSP, which showed an advantage for the rapid preparation.

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