✦ LIBER ✦

Preparation and evaluation of a novel chiral stationary phase based on covalently bonded chitosan for ligand-exchange chromatography

✍ Scribed by Yueqi Liu; Hanfa Zou; Jun Haginaka

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 880 KB
Volume: 29
Category: Article
ISSN: 1615-9306
DOI: 10.1002/jssc.200600015

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✦ Synopsis

Abstract

A novel chiral stationary phase based on chitosan covalently bonded onto silica gels has been prepared and used for the separation of various α‐amino acid enantiomers as well as α‐hydroxycarboxylic acid enantiomers by chiral ligand‐exchange chromatography with copper(II) as a complexing ion. The methanol content and copper(II) ion concentration in the eluent affected retentivity and enantioselectivity. Furthermore, a plausible chiral recognition mechanism for resolution of α‐amino acids was proposed.

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