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Improved Photocontrol of α-Chymotrypsin Activity: Peptidomimetic Trifluoromethylketone Photoswitch Enzyme Inhibitors

✍ Scribed by David Pearson; Nathan Alexander; Andrew D. Abell

Book ID: 101832704
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 310 KB
Volume: 14
Category: Article
ISSN: 0947-6539
DOI: 10.1002/chem.200800082

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✦ Synopsis

Abstract

A series of peptidomimetic trifluoromethylketones containing the photoisomerisable azobenzene group have been synthesised, photoisomerised and assayed against the serine protease α‐chymotrypsin. All are inhibitors of the enzyme and exhibit up to a fivefold increase in activity on UV irradiation. Visible irradiation returns activity to close to that of the original sample. These results suggest the trifluoromethylketone group to be the best electrophilic enzyme binding group for use in photoswitch inhibitors of α‐chymotrypsin.

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