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Improved determination of the bisphosphonate alendronate in human plasma and urine by automated precolumn derivatization and high-performance liquid chromatography with fluorescence and electrochemical detection

โœ Scribed by W.F. Kline; B.K. Matuszewski


Book ID
107997035
Publisher
Elsevier Science
Year
1992
Weight
684 KB
Volume
583
Category
Article
ISSN
0378-4347

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## Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C~18~ column (5โ€‰ฮผm, 250โ€‰mmร—4.6โ€‰mm id) using fluorescence detection with ฮป~ex~=2