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Importance of the α1β1 integrin in acute and chronic intestinal inflammation

✍ Scribed by Kevin P. Pavlick; Christian F. Krieglstein; F. Stephen Laroux; Laura Gray; Jason M. Hoffman; D. Neil Granger; Antonin De Fougerolles; Matthew B. Grisham


Book ID
119427451
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
372 KB
Volume
124
Category
Article
ISSN
0016-5085

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Adhesion to collagens by most cell types is mediated by the integrins a1b1 and a2b1. Both integrin a subunits belong to a group which is characterized by the presence of an I domain in the N-terminal half of the molecule, and this domain has been implicated in the ligand recognition. Since purified