Interaction of type IV collagen with the isolated integrins α1β1 and α2β1
✍ Scribed by Andreas KERN; Johannes EBLE; Ralph GOLBIK; Klaus KÜHN
- Book ID
- 115130106
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 985 KB
- Volume
- 215
- Category
- Article
- ISSN
- 1432-1327
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Collagen type IV provides a biomechanically stable scaffold into which the other constituents of basement membranes are incorporated, but it also plays an important role in cell adhesion. This occurs with collagen type IV mainly via the alpha1beta1 integrin, and the proposed epitope involved in this
Adhesion to collagens by most cell types is mediated by the integrins a1b1 and a2b1. Both integrin a subunits belong to a group which is characterized by the presence of an I domain in the N-terminal half of the molecule, and this domain has been implicated in the ligand recognition. Since purified