Adhesion to collagens by most cell types is mediated by the integrins a1b1 and a2b1. Both integrin a subunits belong to a group which is characterized by the presence of an I domain in the N-terminal half of the molecule, and this domain has been implicated in the ligand recognition. Since purified
✦ LIBER ✦
Importance of Innate Immunity and Collagen Binding Integrin α1β1 in TNBS-Induced Colitis
✍ Scribed by Stefano Fiorucci; Andrea Mencarelli; Barbara Palazzetti; Andrew G Sprague; Eleonora Distrutti; Antonio Morelli; Tatiana I Novobrantseva; Giuseppe Cirino; Victor E Koteliansky; Antonin R de Fougerolles
- Book ID
- 117723305
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 612 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1074-7613
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## Abstract As the prevalence of osteoporosis is expected to increase over the next few decades, the development of novel therapeutic strategies to combat this disorder becomes clinically imperative. These efforts draw extensively from an expanding body of knowledge pertaining to the physiologic me