𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Importance of interferon α in the resistance of allogeneic C57B1/6 mice to the multiplication of friend erythroleukemia cells in the liver

✍ Scribed by Ion Gresser; Chantal Maury; Marie-Thérèse Bandu; Filippo Belardelli

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
757 KB
Volume
45
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Friend erythroleukemia cells (FLC) (H-2d) injected intravenously multiply extensively in the livers of syngeneic DBW2 mice and not at all in the livers of allogeneic C57BV6 mice.

Our results indicate that interferon a (IFN

-a) is an important factor in the resistance of allogeneic mice to the multiplication of FLC in the liver. (a) After i.v. inoculation of FLC there was an inverse correlation between the presence of IFN-a in the serum and the capacity of FLC to multiply in the liver. Thus, all 44 FLC-injected adult C57BV6 mice had circulating IFN-a and FLC did not multiply in the liver of any of the mice. Interferon was not detected in the serum of 83% of 41 FLCinjected DBW2 mice (and was found only at a low titer in 17% of the mice) and FLC multiplied in the liver of all mice. (b) FLC did multiply in the livers of newborn C57B1/6 mice and in the livers of irradiated adult C5761/6 mice, and IFN-a was not detected in their sera. In contrast, after i.v. inoculation of FLC, IFN-a was detected in the sera of 3-week-old and athymic nulnu adult C5761/6 mice while FLC failed to multiply in the liver. (c) FLC also induced IFN-a in congenic BIO.02 (H-Zd) mice and FLC did not multiply in the liver. We suggest that, depending on the site of tumor implantation, different host mechanisms have various degrees of importance in controlling the growth and/or rejection of allogeneic tumor cells, and that IFN-a is particularly important when FLC are injected i.v.

📜 SIMILAR VOLUMES

Interferon-α/β can impede development of
Interferon-α/β can impede development of carcinogen-induced squamous-cell tumors in the esophagus of C57B1 mice
✍ Jan Fagerberg; Carlos Rubio; Ion Gresser; Richard Kuylenstierna; Eva Munck-Wikla 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 519 KB

## Abstract The effect of treatment with murine interferon‐α/β preparations on diethylnitrosamine‐induced squamous‐cell tumors in the esophagus of C57B1 mice was investigated. Diethylnitrosamine was administered in the drinking water for 18 weeks. Interferon was given intraperitoneally during the s

Anti-tumor effects of interferon in mice
Anti-tumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant friend erythroleukemia cells. VIII. Role of the immune system in the inhibition of visceral metastases
✍ Ion Gresser; Chantal Maury; Claude Carnaud; Edward De Maever; Marie-Thérése Maun 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 French ⚖ 758 KB

DBAl2 mice were injected i.v. with IFN alp-resistant 3C I 8 Friend erythroleukemia cells (FLC) which metastasize to the liver and spleen. IFN d p treatment of FLC-injected mice increased their survival time and these mice developed a resistance to a second challenge with FLC. The efficacy of IFN d p

Interferon treatment markedly inhibits t
Interferon treatment markedly inhibits the development of tumor metastases in the liver and spleen and increases survival time of mice after intravenous inoculation of friend erythroleukemia cells
✍ Ion Gresser; Chantal Maury; David Woodrow; Jill Moss; Marcus G. Grütter; Françoi 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 980 KB

respectively. Solid arrows indicate easily visible foci of tumor cells against background of normal hepatic parenchyma. In (c) the hepatic parenchyma is totally replaced by tumor except for small island of normal liver indicated by an open arrow. Hematoxylin and eosin. X 20.