Importance of early detection and follow-up of FLT3 mutations in patients with acute myeloid leukemia
โ Scribed by Natasa Colovic; Natasa Tosic; Sanja Aveic; Marija Djuric; Natasa Milic; Vladimir Bumbasirevic; Milica Colovic; Sonja Pavlovic
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 160 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0939-5555
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๐ SIMILAR VOLUMES
## Abstract Tandem duplication (TD) of the __MLL__ or __FLT3__ gene in acute myeloid leukemia (AML) has been reported. We examined whether TD of these two genes occurs simultaneously. We analyzed 13 AML and 2 myelodysplastic syndrome patients, including 6 adult patients with trisomy 11 and 9 pediat
Mutations affecting NPM, FLT3 ITD and TKD were present in 25% (30/120), 22% (26/120) and 8/120 (7%), respectively. NPM mutations were most prevalent in patients with normal karyotype (24/52; 46%) and were associated with FLT3-ITD mutations (16/26; 62%). Regarding the prognostic significance of NPM a