✦ LIBER ✦

P080 Incidence of FLT-3 mutations in Iranian patients with acute myeloid leukaemia

✍ Scribed by F. Zaker; M. Mohammadi; A. Kazemi

Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 58 KB
Volume: 21
Category: Article
ISSN: 0268-960X
DOI: 10.1016/s0268-960x(07)70158-3

No coin nor oath required. For personal study only.

✦ Synopsis

Mutations affecting NPM, FLT3 ITD and TKD were present in 25% (30/120), 22% (26/120) and 8/120 (7%), respectively. NPM mutations were most prevalent in patients with normal karyotype (24/52; 46%) and were associated with FLT3-ITD mutations (16/26; 62%). Regarding the prognostic significance of NPM and FLT3 mutations, there was no difference in the complete remission rates (CR) between mutation positive and negative patients, but the relapse rate (RR) was significantly increased in the ITD positive group (62% vs. 38%). NPM and FLT3 mutations represent common genetic abnormalities in adult AML. Screening for both mutations is recommended for prognostic stratification of AML (especially of AML with normal karyotype).

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