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Prognostic value of FLT3 mutations among different cytogenetic subgroups in acute myeloid leukemia

✍ Scribed by Fabio P. S. Santos; Dan Jones; Wei Qiao; Jorge E. Cortes; Farhad Ravandi; Elihu E. Estey; Dushyant Verma; Hagop Kantarjian; Gautam Borthakur


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
266 KB
Volume
117
Category
Article
ISSN
0008-543X

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## Background. Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in 20% of adult cases of acute myelogenous leukemia (AML), and this length abnormality was suggested to be associated with leukemic progression. Procedure. We examined the mRNA expression of the FLT3 gene

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## Abstract In this study, we analysed the prognostic relevance of foetal liver tyrosine kinase 3 (FLT3) mutations in 73 patients with acute myeloid leukaemia (AML) with normal karyotype, who survived induction and consolidation and received autologous stem cell transplantation (ASCT) after success