While most of the focus in cancer immunology is on CD8+ cytotoxic T lymphocyte responses, recent evidence indicates that CD4+ T cells are an equally critical component of the antitumor immune response. Successful immunity to cancer will therefore require activation of tumor-specific CD4+ T cells. Tu
Importance of CD4+Helper T-cells in Antitumor Immunity
β Scribed by Hiroshi Shiku
- Book ID
- 105677068
- Publisher
- Carden Jennings Publishing
- Year
- 2003
- Tongue
- English
- Weight
- 234 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0925-5710
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During the past year significant advances have been made in our understanding of the factors contributing to the differentiation of CD4 T helper cell subsets. These have been driven, in part, by the realization that signals (cytokines) from the innate immune response are critical in T cell subset di
## Abstract ## Background Virusβvectored vaccine is a powerful activator of CD8 T cellβmediated immunity and is especially amenable to respiratory mucosal immunization, offering hopes for use in humans with diminished helper CD4 T cell function. However, whether virusβmediated mucosal immunization