In this paper an immunodominant epitope of Topoisomerase I is described. An epitope expression sublibrary was constructed from Topoisomerase I cDNA. The subclones were screened with an antiserum from a patient with systemic sclerosis (SSc). The positive clones defined one immunodominant B cell epito
✦ LIBER ✦
Implications for the Use of Topoisomerase I Inhibitors in Treatment of Patients with Systemic Sclerosis
✍ Scribed by LIDIA RUDNICKA; JOANNA CZUWARA; AGNIESZKA BARUSIŃSKA; URSZULA NOWICKA; BARBARA MAKIELA; STEFANIA JABLONSKA
- Book ID
- 119872965
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 167 KB
- Volume
- 803
- Category
- Article
- ISSN
- 0890-6564
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## Abstract ## Objective Fibroblasts play a crucial role in the development of systemic sclerosis (SSc), and antifibroblast antibodies (AFAs) capable of inducing a proinflammatory phenotype in fibroblasts have been detected in the sera of SSc patients. This study examined the prevalence of AFAs in