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Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells

✍ Scribed by Sven A. Lang; Christina Hackl; Christian Moser; Stefan Fichtner-Feigl; Gudrun E. Koehl; Hans J. Schlitt; Edward K. Geissler; Oliver Stoeltzing

Book ID: 113486357
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 810 KB
Volume: 1803
Category: Article
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2010.01.009

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## Insulin -like growth factors (IGFs) are potent proliferation stimulators for numerous tumor cells and often function as autocrine growth factors. We have previously shown that exogenous IGF-I and IGF-II enhance proliferation of colorectal carcinoma cells. The biological signal of both factors i