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P-53 MECHANISMS OF ANTIBODY-MEDIATED INSULIN-LIKE GROWTH FACTOR I RECEPTOR (IGF-IR) DOWN-REGULATION IN MCF-7 BREAST CANCER CELLS

✍ Scribed by Masahiro Ohtani; Yukiko Yajima; Fujita-Yamaguchi Yoko

Book ID
117734481
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
54 KB
Volume
16
Category
Article
ISSN
1096-6374

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## Abstract Human breast cancer MCF‐7 cells, growth‐arrested by serum starvation, were stimulated with recombinant human insulinlike growth factor‐1 (IGF‐I). An increase in DNA synthesis was induced 20 hr later, which was as effective as that induced by serum. The increase in DNA synthesis was sign