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Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells

✍ Scribed by Sun, Shi-Yong; Yue, Ping; Lotan, Reuben

Book ID: 110064126
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 301 KB
Volume: 19
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1203810

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## Abstract All‐trans‐retinoic acid (ATRA) has been shown to inhibit the growth of a number of ovarian tumor cell lines while others have been found to be resistant to retinoid suppression of growth. Interestingly, two synthetic retinoids, CD437 and 4‐HPR, inhibit the growth of both ATRA‐sensitive