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Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells

✍ Scribed by Yoshiko Satomi; Hoyoku Nishino


Book ID
116272026
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
861 KB
Volume
1790
Category
Article
ISSN
0304-4165

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PDTC, metal chelating compound, induces
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Pyrrolidine dithiocarbamate (PDTC), a metal chelating compound, is known to induce cell death in vascular smooth muscle cells (VSMC). However, the molecular mechanism for PDTC-induced VSMC death is not well understood. Addition of PDTC reduced cell growth and DNA synthesis on VSMC in low density con