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Asiatic Acid, a Triterpene, Induces Apoptosis and Cell Cycle Arrest through Activation of Extracellular Signal-Regulated Kinase and p38 Mitogen-Activated Protein Kinase Pathways in Human Breast Cancer Cells

✍ Scribed by Hsu, Y.-L.


Book ID
126778535
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2004
Tongue
English
Weight
649 KB
Volume
313
Category
Article
ISSN
0022-3565

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## Abstract All‐trans retinoic acid (ATRA), a synthetic derivative of vitamin A, inhibits the growth of breast cancer cells. To elucidate the mechanism by which ATRA causes cell growth inhibition, we examined changes in cell cycle and intracellular signaling pathways, focusing on protein kinase C (