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IMPLICATION OF INVOLVEMENT OF RAT CHROMOSOME #2 IN SPONTANEOUS TRANSFORMATION OF THE RAT-2 CELL LINE

✍ Scribed by L. KRISHNAVENI; S.N. GHOSH

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
829 KB
Volume
20
Category
Article
ISSN
1065-6995

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✦ Synopsis

Abstract

Using an__in vitro__model for cell transformation, the relationship between specific chromosomal aberration and phenotypic changes was studied at different passages of Rat‐2 cell line. A marker chromosome resulting from a translocation [t(2;7)] was found to be associated with focus formation in soft agar. Conversely, the loss of this marker chromosome was found to be associated with phenotypic reversion. These results suggest an association of this marker chromosome with phenotypic transformation for the Rat‐cell line.

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