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FGF2 suppresses neuronogenesis of a cell line derived from rat olfactory epithelium

✍ Scribed by Goldstein, Bradley J. ;Wolozin, Benjamin L. ;Schwob, James E.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 496 KB
Volume: 33
Category: Article
ISSN: 0022-3034
DOI: 10.1002/(sici)1097-4695(199710)33:4<411::aid-neu6>3.0.co;2-d

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✦ Synopsis

Neurogenesis continues throughout veloped markers for GBCs, we characterized the pheadulthood in the mammalian olfactory epithelium notype of the cell line under differing culture condi-(OE), and both neurons as well as nonneuronal cells are reconstituted following experimental injury. Untions. In complete medium, which contains serum and derlying the capacity of the OE to replenish its mature tissue extracts, the cell line displayed characteristics of elements is a population of progenitor basal cells. Al-GBCs that are prominent during regeneration. Serum though the precise lineage relationships among proand extract withdrawal induced the cells to differentigenitor and mature cell types are incompletely underate into neurons. In contrast, FGF2 prevented neustood, the population of globose basal cells (GBCs) ronal differentiation and maintained a GBC phenocontains immediate precursors to neurons as well as type. TGFa had a mitogenic or differentiative effect amplifying progenitors, and retroviral lineage analythat was context dependent. Finally, we demonstrate ses suggest that multipotential GBCs are activated folhere that FGF2 is contained in mature olfactory neulowing direct injury to the OE. To assess the controls rons and sustentacular cells in vivo, suggesting a physion the process of epithelial regeneration, we have ologic role for this growth factor in OE cell regulation. characterized a cell line derived from rat OE and

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