Implementation of dose superimposition to introduce multiple doses for a mathematical absorption model (transit compartment model)
β Scribed by Jun Shen, Alison Boeckmann, Andrew Vick
- Book ID
- 113072087
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 602 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1573-8744
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
It has been shown previously that it is impossible to measure the volume of distribution at steady state conclusively for a multicompartment system from an iv bolus dose only. The problem lies in deciding from which compartment elimination of the drug occurs in the compartmental model. In this paper
In a recent study, Chen and Pelsorl reevaluated the applicability of the half-life approach in the assessment of the relative extent of drug absorption for bioavailabilityl bioequivalence studies. This approach is based on the comparisons of the truncated areas under the curve (AUCs; that is, AUC, )