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Impaired tumor antigen processing by immunoproteasome-expressing CD40-activatedBcells and dendritic cells

โœ Scribed by Karen S. Anderson; Wanyong Zeng; Tetsuro Sasada; Jaewon Choi; Angelika B. Riemer; Mei Su; Donna Drakoulakos; Yoon-Joong Kang; Vladimir Brusic; Catherine Wu; Ellis L. Reinherz


Book ID
105967896
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
541 KB
Volume
60
Category
Article
ISSN
0340-7004

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As CD40 plays a key role in both antitumor immunity and DC maturation, we have studied the regulation of its expression during DC hematopoiesis (dendropoiesis) in vitro and in vivo in the tumor microenvironment. Using MC38 colon adenocarcinoma tumor models, we have demonstrated that DCs generated in