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Impaired T Cell Function in RANTES-Deficient Mice

✍ Scribed by Yasuhiko Makino; Donald N. Cook; Oliver Smithies; Olivia Y. Hwang; Eric G. Neilson; Laurence A. Turka; Hiroshi Sato; Andrew D. Wells; Theodore M. Danoff

Book ID
115593896
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
126 KB
Volume
102
Category
Article
ISSN
1090-2341

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## Abstract The adapter protein CrkL has been implicated in multiple signal transduction pathways in hematopoietic cells. In T lymphocytes, the recruitment of CrkL‐C3G complexes has been correlated with hyporesponsiveness, implicating CrkL as a potential negative regulator. To test this hypothesis