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Impaired regulatory T cell function in germ-free mice

✍ Scribed by Sofia Östman; Carola Rask; Agnes E. Wold; Susanne Hultkrantz; Esbjörn Telemo

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
359 KB
Volume
36
Category
Article
ISSN
0014-2980

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## Abstract The adapter protein CrkL has been implicated in multiple signal transduction pathways in hematopoietic cells. In T lymphocytes, the recruitment of CrkL‐C3G complexes has been correlated with hyporesponsiveness, implicating CrkL as a potential negative regulator. To test this hypothesis