Impaired mitochondrial trafficking in Huntington's disease
โ Scribed by Xiao-Jiang Li; Adam L. Orr; Shihua Li
- Book ID
- 116270784
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 151 KB
- Volume
- 1802
- Category
- Article
- ISSN
- 0925-4439
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## Abstract Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the __ITโ15__ gene; however, it remains unknown how the mutation leads to selective neurodegeneration. Several lines of evidence suggest impaired mitochondrial f
## Abstract ## Background: Huntington's disease (HD) is an autosomal dominant degenerative brain disorder that is characterized by motor, cognitive, and affective symptoms. There is, to some, degree, phenomenological overlap with schizophrenia. Schizophrenia patients are frequently impaired in โth