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Impact of the cyclin–dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

✍ Scribed by Croix, Brad St.; Flørenes, Vivi Ann; Rak, Janusz W.; Flanagan, Mike; Bhattacharya, Nandita; Slingerland, Joyce M.; Kerbel, Robert S.

Book ID
109932187
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
855 KB
Volume
2
Category
Article
ISSN
1078-8956

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## Background and objectives: P27kip1 (p27) plays an important role as a negative regulator of cell cycle-dependent kinase activity during progression of the cell cycle. the most important prognosticator of breast cancer is nodal status, and the aim of this study was to determine the prognostic imp