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Contribution of the cyclin-dependent kinase inhibitor p27KIP1 to the confluence-dependent resistance of HT29 human colon carcinoma cells

✍ Scribed by Marie-Thérèse Dimanche-Boitrel; Olivier Micheau; Arlette Hammann; Monika Haugg; Béatrice Eymin; Bruno Chauffert; Eric Solary


Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
240 KB
Volume
77
Category
Article
ISSN
0020-7136

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio