Genetic toxicology: Impact on the next g
โ
Bernard A. Schwetz; Daniel A. Casciano
๐
Article
๐
1998
๐
John Wiley and Sons
๐
English
โ 34 KB
๐ 1 views
In the early 1970s, we overestimated the range of applicability of the hypothesis that mutations were highly predictive of rodent cancer. Many substances that are nonmutagenesis in current screens are carcinogenic; some genotoxicants are not carcinogenic. Methods of quantitative risk assessment that