Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment
✍ Scribed by T. Ramón y Cajal; A. Altés; L. Paré; E. del Rio; C. Alonso; A. Barnadas; M. Baiget
- Publisher
- Springer US
- Year
- 2009
- Tongue
- English
- Weight
- 177 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0167-6806
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The cytochrome P450 2D6 (CYP2D6) is an enzyme known to metabolize a variety of xenobiotics and drugs. Inter-individual variation in the metabolic capacity of this enzyme has been extensively studied and associations with genotype have been established. Genetic polymorphisms have been grouped as nonf
The study by Okishiro et al 1 concludes that the cytochrome P450 (CYP) genotype CYP2D6\*10/\*10 is unlikely to have a clinically significant impact on prognosis in women with breast cancer who receive adjuvant tamoxifen. However, several aspects of the study by Okishiro et al call their conclusions