The cytochrome P450 2D6 (CYP2D6) is an enzyme known to metabolize a variety of xenobiotics and drugs. Inter-individual variation in the metabolic capacity of this enzyme has been extensively studied and associations with genotype have been established. Genetic polymorphisms have been grouped as nonf
Effect of CYP2D6 polymorphisms on breast cancer recurrence
✍ Scribed by Phuong K. Morrow; Ruben Serna; Kristine Broglio; Lajos Pusztai; D. Michelle Nikoloff; Grantland R. Hillman; Marcel Fontecha; Rui Li; Laura Michaud; Gabriel Hortobagyi; Ana M. Gonzalez-Angulo
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 768 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0008-543X
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## Abstract ## Objective Risperidone is converted to 9‐hydroxyrisperidone by CYP2D6. Two parameters were used to examine the influences of CYP2D6 polymorphism and of co‐medication on risperidone metabolism: the risperidone:9‐hydroxyrisperidone concentration ratio (R:9‐OHR ratio) and the sum of the