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Impact of amino acid substitutions in the core region of HCV on multistep hepatocarcinogenesis

โœ Scribed by Takasuke Fukuhara; Kazuki Takeishi; Takeo Toshima; Kazutoyo Morita; Shigeru Ueda; Tomohiro Iguchi; Shigeyuki Nagata; Keishi Sugimachi; Toru Ikegami; Tomonobu Gion; Yuji Soejima; Akinobu Taketomi; Yoshihiko Maehara

Book ID
118088198
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
279 KB
Volume
40
Category
Article
ISSN
1386-6346

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Amino acid substitutions in hepatitis C
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## Abstract Substitution of amino acid (aa) 70 and/or 91 in the core region of HCV genotype 1b (HCVโ€1b) is an important predictor of hepatocarcinogenesis, but its impact on the development of hepatocellular carcinoma (HCC) following eradication of HCV RNA by antiviral therapy is not clear. 1,273 pa

Amino acid substitutions in the hepatiti
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We showed previously that amino acid (aa) substitutions in hepatitis C virus core region (HCV-CR) are negative predictors of virologic response to pegylated interferon (IFN) plus ribavirin therapy. HCV-CR induces hepatocellular carcinoma in transgenic mice, but the clinical impact is still unclear.