Amino acid substitutions in the Hepatitis C virus core region of genotype 1b in Moroccan patients
β Scribed by Brahim, Ikram; Ezzikouri, Sayeh; Mtairag, El Mostafa; Alaoui, Rhimou; Nadir, Salwa; Pineau, Pascal; Benjelloun, Soumaya
- Book ID
- 121980745
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 184 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1567-1348
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## Abstract Previous studies provided a direct experimental evidence for the contribution of HCV core protein in the development of insulin resistance (IR), but the clinical impact of HCV core region on IR is still not clear. The present study evaluated the impact of Amino acid (aa) substitutions o
We showed previously that amino acid (aa) substitutions in hepatitis C virus core region (HCV-CR) are negative predictors of virologic response to pegylated interferon (IFN) plus ribavirin therapy. HCV-CR induces hepatocellular carcinoma in transgenic mice, but the clinical impact is still unclear.