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Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

✍ Scribed by Irene M. Jones; Cynthia B. Thomas; Bethany Tucker; Claudia L. Thompson; Pavel Pleshanov; Irena Vorobtsova; Dan H. Moore II


Book ID
113395135
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
994 KB
Volume
338
Category
Article
ISSN
0921-8734

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Deletion and insertion in vivo somatic m
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Deletion and insertion mutations have been found to be a major component of the in vivo somatic mutation spectrum in the hypoxanthine phosphoribosyltransferase (hprt) gene of T-lymphocytes. In a population of 172 healthy people (average age, 34; mutant frequency, 10.3 x 10(-6)), deletion/insertion m