Burkhart-Schultz KJ, Jones IM (1997): Deletion and insertion in vivo somatic mutations in the hypoxanthine phosphoribosyltransferase (hprt) gene of human T-lymphocytes. Environ Mol Mutagen 30:371–384

Deletion and insertion in vivo somatic m

Deletion and insertion in vivo somatic mutations in the hypoxanthine phosphoribosyltransferase (hprt) gene of human T-lymphocytes

✍ Karolyn J. Burkhart-Schultz; Irene M. Jones 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 2 views

Deletion and insertion mutations have been found to be a major component of the in vivo somatic mutation spectrum in the hypoxanthine phosphoribosyltransferase (hprt) gene of T-lymphocytes. In a population of 172 healthy people (average age, 34; mutant frequency, 10.3 x 10(-6)), deletion/insertion m