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Immunosuppressive Withanolides from Withania coagulans

✍ Scribed by Chao-Feng Huang; Lei Ma; Li-Juan Sun; Mumtaz Ali; Mohammad Arfan; Jian-Wen Liu; Li-Hong Hu

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 233 KB
Volume: 6
Category: Article
ISSN: 1612-1872
DOI: 10.1002/cbdv.200800211

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✦ Synopsis

Abstract

Six new withanolides, withacoagulins A–F (1–6, resp.), together with ten known withanolides, 7–16, were isolated from the aerial parts of Withania coagulans. Their structures were determined by spectroscopic techniques including 1D‐ and 2D‐NMR (^1^H, ^13^C, HMQC, and HMBC) and MS experiments. These compounds, including the crude extracts of this herb, exhibited strong inhibitory activities on the T‐ and B‐cell proliferation.

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