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Withanolides from Withania adpressa

✍ Scribed by Lalla Hasna Abdeljebbar; Munir Humam; Philippe Christen; Damien Jeannerat; Bruno Vitorge; Saaid Amzazi; Abdelaziz Benjouad; Kurt Hostettmann; Khalid Bekkouche

Publisher
John Wiley and Sons
Year
2007
Tongue
German
Weight
74 KB
Volume
90
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

From the leaves of Withania adpressa, a plant endemic to Sahara of Morocco and Algeria, the novel steroidal lactone (22__R__)‐14__α__,15__α__,17__β__,20__β__‐tetrahydroxy‐1‐oxowitha‐2,5,24‐trien‐26,22‐olide (= (15__S__,17__S__)‐14,15,17,20‐tetrahydroxy‐22,26‐epoxyergosta‐2,5,24‐triene‐1,26‐dione; 1), was isolated, along with three known compounds, withanolides F (2), J (3), and oleanolic acid. Their structures were mainly solved by in‐depth 1D‐ and 2D‐NMR (including ADEQUATE) experiments, as well as by HR‐MS analyses and chemical evidence.

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