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Immunostimulatory CpG oligodeoxynucleotides and antibody therapy of cancer

✍ Scribed by Bernd Jahrsdörfer; George J. Weiner

Book ID
114106627
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
207 KB
Volume
30
Category
Article
ISSN
0093-7754

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## Abstract Oligodeoxynucleotides (ODN) with unmethylated deoxycytidyl‐deoxyguanosine (CpG) dinucleotides (CpG ODN) mimic the immunostimulatory activity of bacterial DNA and are recognized by the Toll‐like receptor 9 (TLR9). CpG ODN of the B‐Class stimulate strong B cell and NK cell activation and