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CpG Oligodeoxynucleotides Enhance Monoclonal Antibody Therapy of a Murine Lymphoma

โœ Scribed by Warren, Thomas L.; Dahle, Christopher E.; Weiner, George J.


Book ID
119935662
Publisher
CIG Media Group, LP.
Year
2000
Tongue
English
Weight
119 KB
Volume
1
Category
Article
ISSN
1526-9655

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A syngeneic anti-idiotype monoclonal antibody (MAb) (CM-I I) directed against an anti-carcinoembryonic antigen (CEA) murine MAb (NP-4) was evaluated as a second antibody (SA) to promote the rapid clearance of radiolabeled NP-4 from the blood. Initial studies confirmed that CM-I I IgG removed l3Il-NP