In vivo immunostimulatory effects of CpG oligodeoxynucleotide in cattle and sheep
β Scribed by A.K Nichani; A Mena; Y Popowych; D Dent; H.G.G Townsend; G.K Mutwiri; R Hecker; L.A Babiuk; P.J Griebel
- Book ID
- 116965241
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 194 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0165-2427
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The immunogenicity of a vaccine formulation is closely related to the effective internalization by the innate immune cells that provide prolonged and simultaneous delivery of antigen and adjuvant to relevant antigen presenting cells. Endosome associated TLR9 recognizes microbial unmethylated CpG DNA
Phosphorothioate oligodeoxynucleotides containing CpG motifs have immunostimulatory activity. Appropriate substitution of deoxynucleosides in the flanking region of CpG-containing phosphorothioate oligodeoxynucleotides with 2'-O-methylribonucleosides results in significant decreases or increases in