✦ LIBER ✦

Immunologic analysis of mononuclear cells in liver tissues and blood of patients with primary sclerosing cholangitis

✍ Scribed by Theresa L. Whiteside; Steven Lasky; Lusheng Si; David H. van Thiel

Book ID: 102850605
Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 842 KB
Volume: 5
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840050321

No coin nor oath required. For personal study only.

✦ Synopsis

Using monoclonal antibodies to surface antigens, we typed and quantitated the mononuclear cells (MNCs) infiltrating liver tissues from 23 patients with primary sclerosing cholangitis. The circulating T lymphocytes were also enumerated by flow cytometry in 12 of these patients. In blood, T lymphocytes and especially T8+ cells were decreased. T cells were the major components of MNCs (78%) in portal tracts. Few of these cells were Tac+ or HLA-DR+. Total MNCs (929 & 90 vs. 106 & 18 in controls) included 11% M1+ and 8% B1+ cells. Aggregates of T4+ and T8+ cells were common in portal areas. The portal T4/TS ratio of 1.27 2 0.1 was significantly (p <

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