Elevation of γδ T lymphocytes in peripheral blood and livers of patients with primary sclerosing cholangitis and other autoimmune liver diseases
✍ Scribed by E B Martins; A K Graham; R W Chapman; K A Fleming
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 345 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
Primary sclerosing cholangitis (PSC) is a chronic cho-may not be their main mechanism of antigen recognilestatic liver disease that is possibly an autoimmune distion. Evidence suggests that they may recognize antiease. Although gd T cells represent a small proportion gen presented by nonpolymorphic MHC molecules such of the total T-cell population in healthy individuals, as CD1. [9] The specificity and function of gd T cells is there is evidence to suggest a role for these cells in autostill unknown, 5 although there has been an increasing immunity. Accordingly, the aim of this study was to innumber of reports associating gd T cells with immunevestigate the population of gd T cells in patients with mediated diseases, including rheumatoid arthritis, 12-14 PSC, compared with other chronic liver diseases. An eleceliac disease, 15 and multiple sclerosis. 16 Elevated vation in the percentage and absolute numbers of gd T numbers were also found in patients with immunodeficells was found in the peripheral blood of patients with ciency disorders that also present with autoimmune PSC (8.66% and 0.13 1 10 06 /L [P õ .01 and õ.05, respectively]) and autoimmune hepatitis (AIH) (8.03% and 0.13 phenomena. 17,18 gd T cells are normally CD4 0 CD8 0 1 10 06 /L [both P õ 0.001]) compared with controls (4.10% (double negative), although they may, on occasions, exand 0.06 1 10 06 /L). We also found an elevation in the press either CD4 / or CD8 / phenotype. 1,19 percentage and absolute numbers of gd T cells in the Primary sclerosing cholangitis (PSC) is a chronic choportal areas of patients with PSC (10.55% and 4.33 [P lestatic liver disease of unknown cause. It leads to proõ .001 and õ .001, respectively]), AIH (7.16% and 4.55 [P gressive obliterating fibrosis of the bile ducts, with the Å .001 and õ .001, respectively]), and primary biliary development of biliary cirrhosis and liver failure. [20][21] cirrhosis (PBC) (5.57% and 3.49 [P Å .008 and õ .001, Evidence suggests that it may be an autoimmune disrespectively]) when compared with controls (2.23% and ease. Thus, there is a relatively disease-specific circu-0.81). These findings suggest a role for gd T cells in the lating autoantibody, [23][24][25][26] an intense mononuclear cell mechanism of immune damage in autoimmune liver diseases. (HEPATOLOGY 1996;23:988-993.)
Abbreviations: MHC, major histocompatibility complex; PSC, primary scleprimary biliary cirrhosis (PBC), and autoimmune heprosing cholangitis; PBC, primary biliary cirrhosis; AIH, autoimmune hepatitis; UC, ulcerative colitis. atitis (AIH), these last two being accepted as autoim-From the