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Immunohistochemical evaluation of O 6 -methylguanine DNA methyltransferase (MGMT) expression in 117 cases of glioblastoma

✍ Scribed by Miyazaki, Masaya; Nishihara, Hiroshi; Terasaka, Shunsuke; Kobayashi, Hiroyuki; Yamaguchi, Shigeru; Ito, Tamio; Kamoshima, Yuuta; Fujimoto, Shin; Kaneko, Sadao; Katoh, Masahito; Ishii, Nobuaki; Mohri, Hiromi; Tanino, Mishie; Kimura, Taichi; Tanaka, Shinya


Book ID
126600022
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
664 KB
Volume
34
Category
Article
ISSN
0919-6544

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O6-methylguanine-DNA methyltransferase g
✍ Christine Rolhion; FrΓ©dΓ©rique Penault-Llorca; Jean-Louis Kemeny; Fabrice Kwiatko πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 169 KB πŸ‘ 2 views

Repair of cytotoxic DNA damage by O 6 -methylguanine-DNA methyltransferase (MGMT) is a potentially important factor of chemoresistance to chloroethylnitrosoureas (CE-NUs), commonly used in the treatment of glioblastoma multiforme (GBM). The value of p53 as a prognostic factor in GBMs remains unclear