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Immunoglobulin from systemic lupus erythematosus serum induces interferon release by normal mononuclear cells

✍ Scribed by Francisco Ramirez; Ralph C. Williams Jr.; Wilmer L. Sibbitt Jr.; Robert P. Searles


Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
908 KB
Volume
29
Category
Article
ISSN
0004-3591

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Polyreactive systemic lupus erythematosus (SLE) B cells were compared with antigen-induced SLE and normal B cells for their interleukin-6 (IL-6) and soluble CD23 requirements. Unlike normal B cells, secretion of antibody by SLE B cells in serum-free medium was not enhanced by exogenous IL-6. Anti-IL